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Article
Purinergic signaling during Porphyromonas gingivalis infection
Biomedical Journal
  • Cassio Luiz Coutinho Almeida-da-Silva, Biophysics Institute of the Federal University of Rio de Janeiro
  • Ana Carolina Morandini, University of the Pacific
  • David M. Ojcius, University of the Pacific
  • Robson Coutinho-Silva, Biophysics Institute of the Federal University of Rio de Janeiro
  • Henning Ulrich, University of São Paulo
ORCiD
David M. Ojcius: 0000-0003-1461-4495, Ana C. Morandini: 0000-0003-4749-571X
Document Type
Article
DOI
10.1016/j.bj.2016.08.003
Publication Date
8-1-2016
Abstract
Despite recent advances unraveling mechanisms of host–pathogen interactions in innate immunity, the participation of purinergic signaling in infection-driven inflammation remains an emerging research field with many unanswered questions. As one of the most-studied oral pathogens, Porphyromonas gingivalis is considered as a keystone pathogen with a central role in development of periodontal disease. This pathogen needs to evade immune-mediated defense mechanisms and tolerate inflammation in order to survive in the host. In this review, we summarize evidence showing that purinergic signaling modulates P. gingivalis survival and cellular immune responses, and discuss the role played by inflammasome activation and cell death during P. gingivalis infection.
Citation Information
Cassio Luiz Coutinho Almeida-da-Silva, Ana Carolina Morandini, David M. Ojcius, Robson Coutinho-Silva, et al.. "Purinergic signaling during Porphyromonas gingivalis infection" Biomedical Journal Vol. 39 Iss. 4 (2016) p. 251 - 260 ISSN: 2319-4170
Available at: http://works.bepress.com/david-ojcius/191/