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Article
Novel and predominant pathogen responsible for the enterovirus-associated encephalitis in eastern China
PLoS One
  • Lei Zhang, Zhejiang Provincial Center for Disease Control and Prevention
  • Jie Yan, Zhejiang University
  • David M. Ojcius, University of California, Merced
  • Huakun Lv, Zhejiang Provincial Center for Disease Control and Prevention
  • Ziping Miao, Zhejiang Provincial Center for Disease Control and Prevention
  • Yin Chen, Zhejiang Provincial Center for Disease Control and Prevention
  • Yanjun Zhang, Zhejiang Provincial Center for Disease Control and Prevention
  • Jvying Yan, Zhejiang Provincial Center for Disease Control and Prevention
ORCiD
David M. Ojcius: 0000-0003-1461-4495
Document Type
Article
DOI
10.1371/journal.pone.0085023
Publication Date
12-30-2013
Abstract
Enteroviruses (EV) have been increasingly identified as the causative agent for unknown etiological encephalitis in many parts of the world, but the long period surveillance for enterovirus-associated encephalitis (EAE) was not reported in China. From 2002-2012 in Zhejiang, Coxsackieviruses A9, B1, B2, B3, B4, B5; and echoviruses 3, 4, 6, 9, 14, 25, 30 were detected from the unknown etiological encephalitis cases, with coxsackievirus B4 been identified here for the first time. From 2002-2004 and 2010-2012, echovirus 30 was found to be the periodically predominant serotype for in the EAE. The molecular typing results showed that all the EV isolates from this study belonged to the human EV B (HEV B) family and were distributed in three clusters.
Comments
Article e85023
Citation Information
Lei Zhang, Jie Yan, David M. Ojcius, Huakun Lv, et al.. "Novel and predominant pathogen responsible for the enterovirus-associated encephalitis in eastern China" PLoS One Vol. 8 Iss. 12 (2013) p. 1 - 5 ISSN: 1932-6203
Available at: http://works.bepress.com/david-ojcius/172/