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Article
Nanoparticle conversion to biofilms: in vitro demonstration using serum-derived mineralo-organic nanoparticles
Nanomedicine
  • Tsui-Yin Wong, Chang Gung University
  • Hsin-Hsin Peng, Chang Gung University
  • Cheng-Yeu Wu, Chang Gung University
  • Jan Martel, Chang Gung University
  • David M. Ojcius, University of the Pacific
  • Fu-Yung Hsu, Ming Chi University of Technology
  • John Ding-E. Young, Chang Gung University
ORCiD
David M. Ojcius: 0000-0003-1461-4495
Document Type
Article
DOI
10.2217/nnm.15.171
Publication Date
12-1-2015
Abstract
Aims: Mineralo-organic nanoparticles (NPs) detected in biological fluids have been described as precursors of physiological and pathological calcifications in the body. Our main objective was to examine the early stages of mineral NP formation in body fluids. Materials & methods: A nanomaterial approach based on atomic force microscopy, dynamic light scattering, electron microscopy and spectroscopy was used. Results: The mineral particles, which contain the serum proteins albumin and fetuin-A, initially precipitate in the form of round amorphous NPs that gradually grow in size, aggregate and coalesce to form crystalline mineral films similar to the structures observed in calcified human arteries. Conclusion: Our study reveals the early stages of particle formation and provides a platform to analyze the role(s) of mineralo-organic NPs in human tissues.
Citation Information
Tsui-Yin Wong, Hsin-Hsin Peng, Cheng-Yeu Wu, Jan Martel, et al.. "Nanoparticle conversion to biofilms: in vitro demonstration using serum-derived mineralo-organic nanoparticles" Nanomedicine Vol. 10 Iss. 24 (2015) p. 3519 - 3535 ISSN: 1743-5889
Available at: http://works.bepress.com/david-ojcius/164/