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MHC and MHC-related proteins as pleiotropic signal molecules
FASEB Journal
  • David M. Ojcius, University of the Pacific
  • Christiane Delarbre
  • Philippe Kourilsky
  • Gabriel Gachelin
David M. Ojcius: 0000-0003-1461-4495
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Class I molecules of the major histocompatibility complex (MHC) have been studied primarily for their role in presenting peptide antigens to conventional T lymphocytes. An increasing body of evidence suggests that MHC and newly characterized MHC-related molecules have a much more varied function in the body. Many of these molecules are involved in pleiotropic interactions with other proteins, which initiate signal transduction cascades and contribute to cellular and tissue homeostasis.
Citation Information
David M. Ojcius, Christiane Delarbre, Philippe Kourilsky and Gabriel Gachelin. "MHC and MHC-related proteins as pleiotropic signal molecules" FASEB Journal Vol. 16 Iss. 2 (2002) p. 202 - 206 ISSN: 0892-6638
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