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Leptospiral hemolysins induce proinflammatory cytokines through Toll-like receptor 2-and 4-mediated JNK and NF-κB signaling pathways
PLoS One
  • Huan Wang, Zhejiang University School of Medicine,
  • Yifei Hu, Zhejiang University School of Medicine,
  • David M. Ojcius, University of California, Merced
  • X. Frank Yang, Indiana University School of Medicine
  • Chenglin Zhang, Zhejiang University School of Medicine,
  • Shibiao Ding, Zhejiang University School of Medicine,
  • Xu'ai Lin, Zhejiang University School of Medicine,
  • Jie Yan, Zhejiang University School of Medicine,
ORCiD
David M. Ojcius: 0000-0003-1461-4495
Document Type
Article
DOI
10.1371/journal.pone.0042266
Publication Date
8-1-2012
Abstract
Infection with pathogenic Leptospira species causes serious systemic inflammation in patients. Although a few leptospiral proinflammatory molecules have been identified, Leptospira likely encodes other unidentified strong inflammation stimulators. The pathogenic L. interrogans genome encodes numerous putative hemolysin genes. Since hemolysins from other bacteria can cause inflammatory reactions, we hypothesized that leptospiral hemolysins may function as proinflammatory stimulators that contribute to the strong inflammation associated with Leptospira infection.
Comments
Article e42266
Citation Information
Huan Wang, Yifei Hu, David M. Ojcius, X. Frank Yang, et al.. "Leptospiral hemolysins induce proinflammatory cytokines through Toll-like receptor 2-and 4-mediated JNK and NF-κB signaling pathways" PLoS One Vol. 7 Iss. 8 (2012) p. 1 - 15 ISSN: 1932-6203
Available at: http://works.bepress.com/david-ojcius/149/