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Article
Inhibition of apoptosis by gamma interferon in cells and mice infected with Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis)
Infection and Immunity
  • Jean-Luc Perfettini, Université Paris
  • Toni Darville, University of Arkansas for Medical Sciences
  • Alice Dautry-Varsat, Institut Pasteur
  • Roger G. Rank, University of Arkansas for Medical Sciences
  • David M. Ojcius, Université Paris
ORCiD
David M. Ojcius: 0000-0003-1461-4495
Document Type
Article
DOI
10.1128/IAI.70.5.2559-2565.2002
Publication Date
5-1-2002
Abstract
The effect of gamma interferon (IFN-γ) on apoptosis due to infection by Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) was studied in epithelial cells in culture and in the genital tracts of mice. IFN-γ concentrations that induce the formation of aberrant, persistent chlamydiae inhibit apoptosis due to C. muridarum infection. In cells treated with an IFN-γ concentration that leads to the development of a heterogenous population of normal and aberrant Chlamydia vacuoles, apoptosis was inhibited preferentially in cells that contained the aberrant vacuoles. The inhibitory effect of IFN-γ appears to be due in part to expression of host cell indoleamine 2,3-dioxygenase activity, since inhibition of apoptosis could be partially reversed through coincubation with exogenous tryptophan. Apoptotic cells were observed in the genital tracts of wild-type mice infected with C. muridarum, and a significantly larger number of apoptotic cells was detected in infected IFN-γ-deficient mice. These results suggest that IFN-γ may contribute to pathogenesis of persistent Chlamydia infections in vivo by preventing apoptosis of infected cells.
Citation Information
Jean-Luc Perfettini, Toni Darville, Alice Dautry-Varsat, Roger G. Rank, et al.. "Inhibition of apoptosis by gamma interferon in cells and mice infected with Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis)" Infection and Immunity Vol. 70 Iss. 5 (2002) p. 2559 - 2565 ISSN: 0019-9567
Available at: http://works.bepress.com/david-ojcius/127/