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Hirsutella sinensis mycelium suppresses interleukin-1b and interleukin-18 secretion by inhibiting both canonical and non-canonical inflammasomes
Scientific Reports
  • Tsung-Teng Huang, Chang Gung University
  • Kowit-Yu Chong, Chang Gung University
  • David M. Ojcius, Chang Gung University
  • Yi-Hui Wu, National Cheng Kung University Hospital
  • Yun-Fei Ko, Chang Gung Biotechnology Corporation
  • Cheng-Yeu Wu, Chang Gung University
  • Jan Martel, Chang Gung University
  • Chia-Chen Lu, Fu Jen Catholic University
  • Hsin-Chih Lai, Chang Gung University
  • John Ding-E. Young, Chang Gung University
ORCiD
David M. Ojcius: 0000-0003-1461-4495
Document Type
Article
DOI
10.1038/srep01374
Publication Date
3-5-2013
Abstract
Cordyceps sinensis is a medicinal mushroom used for centuries in Asian countries as a health supplement and tonic. Hirsutella sinensis—the anamorphic, mycelial form of C. sinensis—possesses similar properties, and is increasingly used as a health supplement. Recently, C. sinensis extracts were shown to inhibit the production of the pro-inflammatory cytokine IL-1β in lipopolysaccharide-treated macrophages. However, the molecular mechanism underlying this process has remained unclear. In addition, whether H. sinensis mycelium (HSM) extracts also inhibit the production of IL-1β has not been investigated. In the present study, the HSM extract suppresses IL-1β and IL-18 secretion, and ATP-induced activation of caspase-1. Notably, we observed that HSM not only reduced expression of the inflammasome component NLRP1 and the P2X7R but also reduced the activation of caspase-4, and ATP-induced ROS production. These findings reveal that the HSM extract has anti-inflammatory properties attributed to its ability to inhibit both canonical and non-canonical inflammasomes.
Comments
Article number: 1374
Citation Information
Tsung-Teng Huang, Kowit-Yu Chong, David M. Ojcius, Yi-Hui Wu, et al.. "Hirsutella sinensis mycelium suppresses interleukin-1b and interleukin-18 secretion by inhibiting both canonical and non-canonical inflammasomes" Scientific Reports Vol. 3 (2013) p. 1 - 11 ISSN: 2045-2322
Available at: http://works.bepress.com/david-ojcius/111/