Professor Kaye's research and teaching focuses on the law of evidence and applications of forensic science, genetics, probability, and statistics in civil and criminal litigation. Professor Kaye's publications include 11 books and more than 180 articles and letters in journals of law, philosophy, psychology, medicine, genetics, and statistics. He has served as editor of the American Bar Association publication, Jurimetrics: The Journal of Law, Science, and Technology, and on committees of the American Statistical Association, the National Academy of Sciences, the National Commission on Forensic Science, the National Commission on the Future of DNA Evidence, the National Institutes of Health, the National Institute of Justice, and the National Institute of Standards and Technology.

Professor Kaye taught evidence, criminal law and procedure, constitutional law, torts, law and science, forensic genetics, forensic economics, statistics, legal philosophy, and international human rights law at universities in the United States, England, and China. Before teaching, he was an associate in a private law firm in Portland, Oregon, an assistant special prosecutor on the Watergate Special Prosecution Force, and a law clerk to Hon. Alfred T. Goodwin, formerly Chief Judge of the U.S. Court of Appeals for the Ninth Circuit.