Early inflammatory and myogenic responses to resistance exercise in the elderlyMuscle and Nerve
AbstractIntroduction and Methods: This study compared changes in myokine and myogenic genes following resistance exercise (3 sets of 12 repetitions of maximal unilateral knee extension) in 20 elderly men (67.8 ± 1.0 years) and 15 elderly women (67.2 ± 1.5 years). Results: Monocyte chemotactic protein (MCP)-1, macrophage inhibitory protein (MIP)-1β, interleukin (IL)-6 and MyoD mRNA increased significantly (P < 0.05), whereas myogenin and myostatin mRNA decreased significantly after exercise in both groups. Macrophage-1 (Mac-1) and MCP-3 mRNA did not change significantly after exercise in either group. MIP-1β, Mac-1 and myostatin mRNA were significantly higher before and after exercise in men compared with women. In contrast, MCP-3 and myogenin mRNA were significantly higher before and after exercise in the women compared with the men. Conclusions: In elderly individuals, gender influences the mRNA expression of certain myokines and growth factors, both at rest and after resistance exercise. These differences may influence muscle regeneration following muscle injury.
Document TypeJournal Article
Access RightsERA Access
Citation InformationJessica L. Mathers, Michelle M. Farnfield, Andrew P. Garnham, Marissa K. Caldow, et al.. "Early inflammatory and myogenic responses to resistance exercise in the elderly" Muscle and Nerve Vol. 46 Iss. 3 (2012) p. 407 - 412 ISSN: 0148-639X
Available at: http://works.bepress.com/david-cameron/6/