Neck pain is a prevalent global malady. Physiotherapists apply joint mobilization (JM) as a routine, pragmatic procedure for neck pain. Perhaps because JM is widely acknowledged as an effective intervention as concluded by multiple systematic reviews and meta-analyses. Unilateral anterior glide (UPA) is an entry-level variant of JM. And the purported rationale of how pain modulation is attained when employing JM is expounded as a neurophysiologic mechanism. Notwithstanding, the neurophysiologic system that alters pain overlaps with blood pressure (BP) as observed in BP-related hypoalgesia. Therefore, BP is a pertinent and easily quantified variable to examine. Nonetheless, there is scant evidence on the cardiovascular response to UPA. Moreover, it is unsettled whether JM produces sympatho -excitatory or -inhibitory reaction as determined by two published reports that employed central anterior glide (CPA) and unilateral posterior pressures (AP), respectively.