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Selected Works of David Bangsberg
Article
HIV Infection and Arterial Stiffness among Older-adults taking Antiretroviral Therapy in Rural Uganda
AIDS (2016)
  • Mark J. Siedner, Center for Global Health, Massachusetts General Hospital
  • June-Ho Kim
  • Ruth Sentongo Nakku
  • Linda Hemphill
  • Virginia A. Triant
  • Jessica Haberer, Massachusetts General Hospital
  • Jeffrey N. Martin
  • Yap Boum, Mbarara University of Science & Technology
  • Douglas S. Kwon
  • Alexander C. Tsai
  • Peter W. Hunt
  • Samson Okello
  • David R. Bangberg, Portland State University
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Abstract
HIV infection is associated with arterial stiffness, but no studies have assessed this relationship in sub-Saharan Africa. We enrolled 205 participants over 40 years old in Uganda: 105 on antiretroviral therapy for a median of 7 years, and a random sample of 100 age and sex-matched HIV-uninfected controls from the clinic catchment area. The prevalence of arterial stiffness (ankle brachial index  > 1.2) was 33%, 18%, 19% and 2% in HIV+ men, HIV- men, HIV+ women, and HIV- women. In multivariable models adjusted for cardiovascular risk factors, HIV+ individuals had over double the prevalence of arterial stiffness (adjusted prevalence ratio 2.86, 95% confidence interval 1.41-5.79, P = 0.003).

At the time of writing, David Bangsberg was affiliated with Harvard Medical School and Massachusetts General Hospital.
Keywords
  • HIV infection,
  • Arterial stiffness,
  • sub-Saharan Africa,
  • Antiretroviral therapy
Disciplines
Publication Date
February, 2016
DOI
10.1097/QAD.0000000000000992
Publisher Statement
Copyright © 2016 Wolters Kluwer Health, Inc.
Citation Information
Siedner, M. J., Kim, J. H., Nakku, R. S., Hemphill, L., Triant, V. A., Haberer, J. E., ... & Hunt, P. W. (2016). HIV infection and arterial stiffness among older-adults taking antiretroviral therapy in rural Uganda. Aids, 30(4), 667-670.