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Selected Works of David Bangsberg
Article
Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome
Cell Host & Microbe (2016)
  • Cynthia L. Monaco, Washington University School of Medicine
  • David B. Gootenberg, Ragon Institute of MGH, MIT, and Harvard
  • Guoyan Zhao, Washington University School of Medicine
  • Scott A. Handley, Washington University School of Medicine
  • Musie S. Ghebremichael, Ragon Institute of MGH, MIT, and Harvard
  • Efrem S. Lim, Washington University School of Medicine
  • Alex Lankowski, Massachusetts General Hospital
  • Megan T. Baldridge, Washington University School of Medicine
  • Craig B. Wilen, Washington University School of Medicine
  • Meaghan Flagg, Ragon Institute of MGH, MIT, and Harvard
  • Jason M. Norman, Vedanta Biosciences
  • Brian C. Keller, Washington University School of Medicine
  • Jesùs Mario Luévano, Ragon Institute of MGH, MIT, and Harvard
  • David Wang, Washington University School of Medicine
  • Yap Boum, Médecins Sans Frontières Epicentre
  • Jeffrey N. Martin, University of California San Francisco
  • Peter W. Hunt, University of California San Francisco
  • David R. Bangberg, Portland State University
  • Mark J. Siedner, Center for Global Health, Massachusetts General Hospital
  • Douglas S. Kwon, Ragon Institute of MGH, MIT, and Harvard
  • Herbert W. Virgin, Washington University School of Medicine
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Abstract
Human immunodeficiency virus (HIV) infection is associated with increased intestinal translocation of microbial products and enteropathy as well as alterations in gut bacterial communities. However, whether the enteric virome contributes to this infection and resulting immunodeficiency remains unknown. We characterized the enteric virome and bacterial microbiome in a cohort of Ugandan patients, including HIV-uninfected or HIV-infected subjects and those either treated with anti-retroviral therapy (ART) or untreated. Low peripheral CD4 T cell counts were associated with an expansion of enteric adenovirus sequences and this increase was independent of ART treatment. Additionally, the enteric bacterial microbiome of patients with lower CD4 T counts exhibited reduced phylogenetic diversity and richness with specific bacteria showing differential abundance, including increases in Enterobacteriaceae, which have been associated with inflammation. Thus, immunodeficiency in progressive HIV infection is associated with alterations in the enteric virome and bacterial microbiome, which may contribute to AIDS-associated enteropathy and disease progression.

Note: At the time of writing, David Bangsberg was affiliated with Massachusetts General Hospital and Harvard Medical School.
Keywords
  • Virome,
  • Microbiome,
  • HIV,
  • AIDS,
  • Adenovirus,
  • AIDS enteropathy,
  • Systemic inflammation
Disciplines
Publication Date
March 9, 2016
DOI
10.1016/j.chom.2016.02.011
Publisher Statement
Copyright © 2016 Elsevier Inc. All rights reserved.
Citation Information
115. Monaco CL, Gootenberg DB, Zhao G, Handley SA, Ghebremichael MS, Lim ES, Lankowski A, Baldridge MT, Wilen CB, Flagg M, Norman JM, Keller BC, Luévano JM, Wang D, Boum Y, Martin JN, Hunt PW, Bangsberg DR, Siedner MJ, Kwon DS, Virgin HW. Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome. Cell Host Microbe. 2016 Mar 9;19(3):311-322.