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SITEHOUND-web: a server for ligand binding site identification in protein structures
Nucleic Acids Research
  • Marylens Hernandez
  • Dario Ghersi, University of Nebraska at Omaha
  • Roberto Sanchez
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SITEHOUND-web ( is a binding-site identification server powered by the SITEHOUND program. Given a protein structure in PDB format SITEHOUND-web will identify regions of the protein characterized by favorable interactions with a probe molecule. These regions correspond to putative ligand binding sites. Depending on the probe used in the calculation, sites with preference for different ligands will be identified. Currently, a carbon probe for identification of binding sites for drug-like molecules, and a phosphate probe for phosphorylated ligands (ATP, phoshopeptides, etc.) have been implemented. SITEHOUND-web will display the results in HTML pages including an interactive 3D representation of the protein structure and the putative sites using the Jmol java applet. Various downloadable data files are also provided for offline data analysis.

© 2009 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citation Information
Marylens Hernandez, Dario Ghersi and Roberto Sanchez. "SITEHOUND-web: a server for ligand binding site identification in protein structures" Nucleic Acids Research Vol. 37 Iss. 2 (2009) p. W413 - W416
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