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Article
CD8 memory T cells: cross-reactivity and heterologous immunity
Seminars in Immunology
  • Liisa K. Selin, University of Massachusetts Medical School
  • Markus Cornberg, University of Massachusetts Medical School
  • Michael A. Brehm, University of Massachusetts Medical School
  • Sung-Kwon Kim, University of Massachusetts Medical School
  • Claudia Calcagno, University of Genoa
  • Dario Ghersi, University of Nebraska at Omaha
  • Roberto Puzone
  • Franco Celada, University of Genoa
  • Raymond M. Welsh, University of Massachusetts Medical School
Document Type
Article
Publication Date
10-1-2004
Disciplines
Abstract
Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The degeneracy of T cell antigen recognition and the flexibility of diverse antigen-specific repertoires allow the host to respond to a multitude of pathogens while accommodating these numerous large memory pools in a finite immune system. These cross-reactive memory T cells can be employed in immune responses and mediate protective immunity, but they can also induce life-threatening immunopathology or impede transplantation tolerance and graft survival. Here we discuss examples of altered viral pathogenesis occurring as a consequence of heterologous T cell immunity and propose models for the maintenance of a dynamic pool of memory cells.
Citation Information
Liisa K. Selin, Markus Cornberg, Michael A. Brehm, Sung-Kwon Kim, et al.. "CD8 memory T cells: cross-reactivity and heterologous immunity" Seminars in Immunology Vol. 16 Iss. 5 (2004) p. 335 - 347
Available at: http://works.bepress.com/dario-ghersi/15/