CD8 memory T cells: cross-reactivity and heterologous immunitySeminars in Immunology
AbstractVirus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The degeneracy of T cell antigen recognition and the flexibility of diverse antigen-specific repertoires allow the host to respond to a multitude of pathogens while accommodating these numerous large memory pools in a finite immune system. These cross-reactive memory T cells can be employed in immune responses and mediate protective immunity, but they can also induce life-threatening immunopathology or impede transplantation tolerance and graft survival. Here we discuss examples of altered viral pathogenesis occurring as a consequence of heterologous T cell immunity and propose models for the maintenance of a dynamic pool of memory cells.
Citation InformationLiisa K. Selin, Markus Cornberg, Michael A. Brehm, Sung-Kwon Kim, et al.. "CD8 memory T cells: cross-reactivity and heterologous immunity" Seminars in Immunology Vol. 16 Iss. 5 (2004) p. 335 - 347
Available at: http://works.bepress.com/dario-ghersi/15/