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Article
Beyond structural genomics: computational approaches for the identification of ligand binding sites in protein structures
Journal of Structural and Functional Genomics
  • Dario Ghersi, University of Nebraska at Omaha
  • Roberto Sanchez, Mount Sinai School of Medicine
Document Type
Article
Publication Date
7-1-2011
Abstract
t Structural genomics projects have revealed structures for a large number of proteins of unknown function. Understanding the interactions between these proteins and their ligands would provide an initial step in their functional characterization. Binding site identification methods are a fast and cost-effective way to facilitate the characterization of functionally important protein regions. In this review we describe our recently developed methods for binding site identification in the context of existing methods. The advantage of energy-based approaches is emphasized, since they provide flexibility in the identifi- cation and characterization of different types of binding sites
Comments

The final publication is available at Springer via http://link.springer.com/article/10.1007%2Fs10969-011-9110-6.

Citation Information
Dario Ghersi and Roberto Sanchez. "Beyond structural genomics: computational approaches for the identification of ligand binding sites in protein structures" Journal of Structural and Functional Genomics Vol. 12 Iss. 2 (2011) p. 109 - 117
Available at: http://works.bepress.com/dario-ghersi/12/