Article
Palladium(II)-Catalyzed Dicarboxymethylation of Chiral Allylic Alcohols: Chirality Transfer Affording Optically Active Diesters Containing Three Contiguous Chiral Centers
Tetrahedron Letters
Document Type
Article
Publication Date
7-7-2010
Pages
3514-3517
Publisher Name
Elsevier
Disciplines
Abstract
This manuscript describes the extension of Stille’s palladium-catalyzed olefin dicarbonylation reaction to chiral allylic alcohols with chirality transfer to afford the corresponding chiral alcohol functionalized with bis-carbomethoxy esters, containing three contiguous chiral centers, in good to excellent diastereoselectivities (78–98%).
Creative Commons License
Creative Commons Attribution-Noncommercial-No Derivative Works 3.0
Copyright Statement
© 2010 Elsevier
Citation Information
Othman Hamed, Patrick M. Henry and Daniel P. Becker. "Palladium(II)-Catalyzed Dicarboxymethylation of Chiral Allylic Alcohols: Chirality Transfer Affording Optically Active Diesters Containing Three Contiguous Chiral Centers" Tetrahedron Letters Vol. 51 Iss. 27 (2010) Available at: http://works.bepress.com/daniel_p_becker/81/
Author Posting © Elsevier, 2010. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Tetrahedron Letters , Volume 51, Issue 27, July 7, 2010. http://dx.doi.org/10.1016/j.tetlet.2010.04.105