Article
MMP-13 Selective Alpha-sulfone Hydroxamates: Identification of Selective P1' Amides
Bioorganic & Medicinal Chemistry Letters
Document Type
Article
Publication Date
5-15-2011
Pages
2823-2825
Publisher Name
Elsevier
Disciplines
Abstract
Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1' substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold selectivity for MMP-13 versus MMP-2 and -8.
Creative Commons License
Creative Commons Attribution-Noncommercial-No Derivative Works 3.0
Copyright Statement
© 2011 Elsevier
Citation Information
Yvette M. Fobian, John N. Freskos, Thomas E. Barta, Louis J. Bedell, et al.. "MMP-13 Selective Alpha-sulfone Hydroxamates: Identification of Selective P1' Amides" Bioorganic & Medicinal Chemistry Letters Vol. 21 Iss. 10 (2011) Available at: http://works.bepress.com/daniel_p_becker/28/
Author Posting © Elsevier, 2011. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 10, May 15, 2011. http://dx.doi.org/10.1016/j.bmcl.2011.03.095