Use of Atom-transfer Radical Cyclizations as an Efficient Entry into a New Serotonergic NorazaadamantaneTetrahedron Letters
AbstractA route to azanoradamantanes is described which makes use of an atom-transfer radical cyclization to afford 3-azabicyclo[3.3.0]octanes 3A and 3B. Subsequent elaboration of exo-allylamine functionality, followed by cyclization of the endo-hydroxymethyl intermediate 9, affords the new azanoradamantanes 11 and 4. This new azatricyclic system is useful for producing serotonin 5-HT3 antagonists and 5-HT4 agonists.
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Copyright Statement© 1992 Elsevier
Citation InformationDaniel L. Flynn, Daniel Becker, Roger Nosal and Daniel Zabrowksi. "Use of Atom-transfer Radical Cyclizations as an Efficient Entry into a New Serotonergic Norazaadamantane" Tetrahedron Letters Vol. 33 Iss. 48 (1992)
Available at: http://works.bepress.com/daniel_p_becker/17/