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Article
Serotonin 5-HT4 Agonist Activity of a Series of Meso-Azanoradamantane Benzamides
Bioorganic & Medicinal Chemistry Letters
  • Daniel Becker, Loyola University Chicago
  • Roger Nosal
  • Clara I. Villamil
  • Gary Gullikson
Document Type
Article
Publication Date
9-9-1997
Publisher Name
Elsevier
Disciplines
Abstract

A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT4agonist in the series, with an EC50 of 217 nM.

Comments
Author Posting © Elsevier, 1997. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 7, Issue 17, September 9, 1997. http://dx.doi.org/10.1016/S0960-894X(97)00408-3
Creative Commons License
Creative Commons Attribution-Noncommercial-No Derivative Works 3.0
Citation Information
Daniel Becker, Roger Nosal, Clara I. Villamil and Gary Gullikson. "Serotonin 5-HT4 Agonist Activity of a Series of Meso-Azanoradamantane Benzamides" Bioorganic & Medicinal Chemistry Letters Vol. 17 Iss. 1 (1997)
Available at: http://works.bepress.com/daniel_p_becker/14/