|2004 ‐ Present||Associate Professor of Chemistry, Loyola University Chicago, Loyola University Chicago ‐ Department of Chemistry and Biochemistry|
Language Learning (1)
Featured Works (29)
Rearrangement of Cyclotriveratrylene (CTV) Diketone: 9,10-Diarylanthracenes with OLED Applications
Journal of Organic Chemistry (2013)
Electroluminescent 9,10-diaryl anthracenes have been shown to be promising host and hole-transporting materials in organic electroluminescence due to their high ...
Synthesis, Crystal Structure, and Rearrangements of ortho-Cyclophane Cyclotetraveratrylene (CTTV) tetraketone
Supramolecular Chemistry (2012)
Oxidation of cyclotetraveratrylene (CTTV) with potassium permanganate in pyridine under reflux gave tetraketone (the ketonand) 3 which exists as a ...
Orally Bioavailable Dual MMP-1/MMP-14 Sparing, MMP-13 Selective Alpha-sulfone Hydroxamates
Bioorganic & Medicinal Chemistry Letters (2010)
A series of phenyl piperidine α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies ...
Synthesis and Structure-Activity Relationships of ß- and a-Piperidine Sulphone Hydroxamic ...
Journal of Medicinal Chemistry (2005)
α-Piperidine-β-sulfone hydroxamate derivatives were explored that are potent for matrix metalloproteinases (MMP)-2, -9, and -13 and are sparing of MMP-1. ...
Azaadamantane Benzamide 5-HT4 Agonists: Gastrointestinal Prokinetic SC-54750
Bioorganic & Medicinal Chemistry Letters (2004)
Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a–d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 ...
Alpha-Alkyl-alpha-amino-beta-sulphone Hydroxamates as Potent MMP Inhibitors that Spare MMP-1
Bioorganic & Medicinal Chemistry Letters (2001)
A series of α-alkyl-α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MMP-2 and MMP-13, and for selectivity versus MMP-1. ...
Enantioselective Synthesis of Dual Serotonergic Azanoradamantane SC-52491
Tetrahedron Letters (1999)
A racemic synthesis of azanoradamantane (±)-3 was accomplished via Yamamoto's MAD-catalyzed Diels-Alder protocol. Subsequently, a scalable asymmetric synthesis of azanoradamantane ...
Serotonin 5-HT4 Agonist Activity of a Series of Meso-Azanoradamantane Benzamides
Bioorganic & Medicinal Chemistry Letters (1997)
A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4agonism activity in the rat tunica muscularis mucosae (TMM) ...
Synthetic Strategies for the Construction of Enantiomeric Azanoradamantanes
Tetrahedron Letters (1997)
The amino azanoradamantane hexahydro-2,5b-methano-IH-3aS,3aa,6aa-cyclopenta-[clpyrrole-4a-amine 1and the corresponding enantiomer ent-1 have been prepared along with benzamide derivatives SC-52491and SC-52490, respectively, which ...
Preparation of Trifluoromethyl Lactol Derivatives via Base Initiated Cyclobutanol Ring ...
Benzocyclobutenone derivatives 4 are converted to the corresponding trifluoromethylcyclobutanols 5 by treatment with trifluoromethyltrimethylsilane in the presence of tetra-n-butylammonium fluoride. ...
Synthesis of N-BOC-3-azabicyclo[3.3.0]octan-7-one via reductive pauson-khand ...
Tetrahedron Letters (1993)
An intramolecular reductive Pauson-Khand reaction of the hexacarbonyldicobalt complex of N-(tert-butyloxycarbonyl)allylpropargylamine under dry-state adsorption conditions directly afforded the saturated N-BOC-3-azabicyclo[3.3.0]octan-7-one ...