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Selected Works of Daniel Fologea
Article
Multivalent Ions Control the Transport Through Lysenin Channels
Biophysical Chemistry (2010)
  • Daniel Fologea, University of Arkansas
  • Eric Krueger, University of Arkansas
  • Redwan Al Faori, University of Arkansas
  • Rachel Lee, University of Arkansas
  • Yuriy I. Mazur, University of Arkansas
  • Ralph Henry, University of Arkansas
  • Mark Arnold, University of Arkansas
  • Greg J. Salamo, University of Arkansas
Link
Abstract
We report the effect of different ions on the conducting properties of lysenin channels inserted into planar lipid bilayer membranes. Our observations indicated that multivalent ions inhibited the lysenin channels conductance in a concentration dependent manner. The analysis performed on single channels revealed that multivalent ions induced reversible sub-conducting or closed states depending on the ionic charge and size. Good agreement is reported between experimental results and a theoretical model that is proposed to describe the interaction between divalent ions and lysenin channels as a simple isothermal absorption process.
Keywords
  • Lysenin,
  • Pore forming toxins,
  • Ligand gated channels,
  • Multivalent ions
Disciplines
Publication Date
November, 2010
Citation Information
Daniel Fologea, Eric Krueger, Redwan Al Faori, Rachel Lee, et al.. "Multivalent Ions Control the Transport Through Lysenin Channels" Biophysical Chemistry Vol. 152 Iss. 1-3 (2010)
Available at: http://works.bepress.com/daniel_fologea/2/