Alternative methods for orthopedic fixation can be classified into bio-absorbable and bio-incorporative methods. Bio-absorbable materials such as polyglycolic acid and polydioxanone are eliminated from the body over time while bio-incorporative materials such as ceramics and glasses, and human cortical bone eventually form part of the body. Polyglycolic acid shows potential in reducing fracture in the extremities. Cortical bone exhibits high elastic moduli and mechanical toughness suitable for pins and fasteners in the upper extremities, principally the hand and wrist. Bio-glass shows potential for stimulating new bone growth and can also be used in fracture fixation.