Article
The Brief Case: Recurrent Chromobacterium violaceum Bloodstream Infection in a Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient Patient with a Severe Neutrophil Defect
Journal of Clinical Microbiology
(2020)
Abstract
A 37-year-old male with a medical history of glucose-6-phosphate dehydrogenase (G6PD) deficiency (Beaumont variant) presented at the emergency department (ED) with fatigue, malaise, generalized joint pains, and chills. On exam, he was febrile (40.2°C) and tachycardic (143 beats/min) while normotensive (124/75 mm Hg) and oxygenating well on ambient air (99% SpO2). His blood chemistries were remarkable, with elevated lactic acid at 3.27 mmol/liter (range, 0.5 to 2.20 mmol/liter) and procalcitonin at 0.35 ng/ml (range, <0.05 ng/ml). Additional lab findings showed a normal white blood cell (WBC) count (7,192 cells/μl; range, 4,000 to 11,000/μl), with 80% neutrophils, and signs of acute hemolytic anemia, with high reticulocytes at >17.97% (range, 0.59 to 2.24%), low hemoglobin (Hgb; 9.9 mg/dl; range, 12.2 to 16.4 mg/dl), hyperbilirubinemia (unconjugated bilirubin, 3 mg/dl; range, 0.1 to 1.1 mg/dl), and high ferritin level (3,240 ng/ml; range, 18 to 464 ng/ml). He was given a dose of 1 g meropenem intravenously (i.v.) and admitted for further management of suspected septicemia.
Disciplines
Publication Date
January 28, 2020
DOI
10.1128/JCM.00312-19
Citation Information
Phyu M. Thwe, Daniel A. Ortiz, Alyssa L. Wankewicz, J. Patrik Hornak, et al.. "The Brief Case: Recurrent Chromobacterium violaceum Bloodstream Infection in a Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient Patient with a Severe Neutrophil Defect" Journal of Clinical Microbiology Vol. 58 Iss. 2 (2020) p. e00312 - e00319 Available at: http://works.bepress.com/daniel-ortiz/7/