Article
Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors.
Cancers (Basel)
Document Type
Article
Publication Date
4-27-2020
Disciplines
Abstract
This study examined the role of the ubiquitin E3-ligase RNF123 in modulating downstream NF-κB1 targets in glioblastoma (GB) tumor progression. Our findings revealed an oncogenic pathway (miR-155-5p-RNF123-NF-κB1-p50-SerpinE1) that may represent a new therapeutic target pathway for GB patients with isocitrate dehydrogenase 1 and 2 (
Area of Special Interest
Cancer
Specialty/Research Institute
Oncology
Citation Information
Xiaowen Wang, Matias A Bustos, Xiaoqing Zhang, Romela Irene Ramos, et al.. "Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors." Cancers (Basel) (2020) Available at: http://works.bepress.com/daniel-kelly/235/