Article
Cannabidiol Exposure During Gestation Leads to Adverse Cardiac Outcomes Early in Postnatal Life in Male Rat Offspring
Cannabis and Cannabinioid Research
(2024)
Abstract
Studies indicate that *7% of pregnant individuals in North America consume cannabis in pregnancy. Pre-clinical studies have established that maternal exposure to D9-tetrahydrocannabinol (THC; major psychoactive component in cannabis) leads to fetal growth restriction and impaired cardiac function in offspring. However, the effects of maternal exposure to cannabidiol (CBD; major non-euphoric constituent) on cardiac outcomes in offspring remain unknown. Therefore, our objective is to investigate the functional and underlying molecular impacts in the hearts of offspring exposed to CBD in pregnancy.
Keywords
- cannabidiol,
- cannabis,
- pregnancy,
- cardiac outcomes,
- cardiac output,
- endocannabinoid system,
- CBD
Disciplines
Publication Date
Winter February 15, 2024
DOI
0.1089/can.2023.0213
Citation Information
Daniel B Hardy, Kendrick Lee, Steven R Laviolette, David R Natale, et al.. "Cannabidiol Exposure During Gestation Leads to Adverse Cardiac Outcomes Early in Postnatal Life in Male Rat Offspring" Cannabis and Cannabinioid Research (2024) ISSN: 2378-8763 Available at: http://works.bepress.com/daniel-hardy/48/