We compare experimental fully differential three-dimensional angular distributions of electrons ionized from He in collision with ionic projectiles covering a broad range of perturbations (0.065 to 4.4). Even at very small perturbations clear signatures of higher-order contributions are observable. At large perturbations, such contributions become even dominant, especially those involving the post-collision interaction between the outgoing projectile and the ionized electron. Our results show that single ionization is not nearly as well understood as was assumed previously.