For the first time we investigated in a kinematically complete experiment the ionization of helium in collisions with H2+-molecular ions at 1 MeV. Using two separate detectors, the orientation of the projectile H2+-molecular ions was determined at the instance of the collision. The electron angular distribution was measured by a "Reaction Microscope". The observed structures are found in agreement with theoretical calculations, indicating that the ionized electron of He shows a slight preferential emission direction parallel to the molecular axis.