Recent increases in the delinquency and incarceration of girls have prompted juvenile justice professionals to search for effective, gender-specific prevention and treatment strategies. Given the dearth of research on girls' programming, these professionals are often left to sort out discrepancies between two major bodies of literature that address the needs of delinquent girls—the “what works” literature and the “gender-responsive” literature. This article culls the best of what is available within both these bodies of literature and suggests programmatic elements deemed essential for working effectively with girls.