A systematic review of virtual reality (VR) systems for individuals diagnosed with autism spectrum disorder (ASD) is detailed. The aim of this proceeding is to determine which social skills focuses are most important and how their potential improvements should be measured. Following the PRISMA guidelines, 48 articles were identified, and a total of 12 articles that met the a priori criteria were given full review. All 12 studies aimed to train some social skill, but there was no agreement among which single theme was most essential. The ones that received the most attention were facial expression and emotion recognition, appropriate behaviors and responses, and initiating social interactions. Only 9 studies used direct measures to assess changes made as a result of the VR systems. The ones most commonly used were subjective measures and participants’ body movements and gestures. The collective impacts and limitations of the studies are presented, as well as implications for future work.