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Article
Biophysical Properties of a Chloride Channel in the Apical Membrane of a Secretory Epithelial Cell
Comparative Biochemistry and Physiology Part A: Physiology
  • Dan R. Halm, Wright State University - Main Campus
  • Gerhard Rechkemmer
  • Robert A. Schoumacher
  • Raymond A. Frizzell
Document Type
Article
Publication Date
1-1-1988
Abstract
1. Patch clamp studies on colonic tumor cell line T84 show the presence of chloride channels. 2. The channels are activated by forskolin, PGE2, or 8-Br-cAMP. 3. Single channel conductance was ca 40 pS at the reversal potential, increasing to 70 pS at +80mV and decreasing to 25 pS at −80 mV. 4. Relative permeabilities were I > Br > Cl > F.
DOI
10.1016/0300-9629(88)90673-1
Citation Information
Dan R. Halm, Gerhard Rechkemmer, Robert A. Schoumacher and Raymond A. Frizzell. "Biophysical Properties of a Chloride Channel in the Apical Membrane of a Secretory Epithelial Cell" Comparative Biochemistry and Physiology Part A: Physiology Vol. 90 Iss. 4 (1988) p. 597 - 601 ISSN: 10964940
Available at: http://works.bepress.com/dan_halm/47/