The purpose of this study was to examine the changes in running economy and maximal oxygen consumption (VO2 max) of cross-country runners with cross-training on the PowerCranks™. Seven men and 6 women completed 6 wks of stationary cycle ergometer training using either the PowerCranks™ or the standard cranks (control group). The subjects trained 3 d wk-1 at 60 rev·min-1 at 3 to 3.5 kg for 30 min, which increased to 40 min after the 3rd wk and 50 min after the 4th wk, with a 48-h minimum between training sessions. Pre-and post-running economy and VO2 max were measured. There were no significant differences in running economy or VO2 max after training in either the control or the PowerCranks™ group. Further, the difference in change scores for running economy between the PowerCranks™ (0.102 ± 0.101 L min-1) and the control (0.010 ± 0.108 L min-1) groups was not significant (P=0.15). Cross-training for 6 wks with independent cycle cranks 3 d wk-1 had no effect on the running economy or VO2 max of highly-trained collegiate distance runners.