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n-glycan profiling
  • Melissa George
As it is known to all that qualitatively matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) represents high sensitivity and robustness for the structural characterization of glycosylated compounds and can also be used in a high-throughput manner. It is also the preference for singly charged ion formation that makes MALDI a better choice than electrospray ionization for profiling mixtures of N-glycans. The substrates of N-Glycan profiling are permethylated glycans. That is to say, n-glycan profiling by enzymatic deglycosylation using Peptide N-glycosidase A or F is analyzed after permethylation.
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Melissa George. "n-glycan profiling" (2017)
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