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oxylipins
(2017)
  • Melissa George
Abstract
Oxylipins are defined as oxygenated metabolites derived from poly-unsaturated fatty acids (PUFAs) such as arachidonic acid (AA), eicosapentaenoic acid (EPA), linoleic acid (LA), and dihomo-γ-linolenic acid (DGLA) and docosahexaenoic acid (DHA). These PUFAs are transformed into a variety of oxylipins through either enzymatic or non-enzymatic oxidation processes. Three main classes of enzymes- cytochrome P450 (CYP450), cyclooxygenase (COX) and lipoxygenase (LOX) -play important roles in the generation of the complex pool of bioactive components from the different precursor PUFAs. Eicosanoids, the best-described lipid mediators, are those biologically active lipid mediators derived from C20 fatty acids, such as prostaglandins, thromboxanes, leukotrienes and related oxygenated derivatives. Oxylipins, affect a broad range of biological processes such as host defense, tissue injury, and surgical intervention and responses to cardiovascular diseases.
Disciplines
Publication Date
2017
Citation Information
Melissa George. "oxylipins" (2017)
Available at: http://works.bepress.com/creativeproteomics/20/