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cyp450 metabolites
  • Melissa George
Arachidonic acid (AA) is a widely distributed polyunsaturated fatty acid once liberated from phospholipids by phospholipases. AA can undergo either monooxygenation or epoxidation by enzymes in the cytochrome P450 (cyp450 metabolites) family. CYP-AA metabolites include 19- and 20-hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs) and diHETEs. These metabolites have different biological functions based on sites of production- the endothelium of vessels in many organs, the lung, the tubular and corneal epithelium, the liver. The likely targets are either enzymes (Na+-K+-ATPase) or ion channels (calcium activated potassium channels). The involvement of conventional receptor physiology in the tissue responses to CYP-AA products remains an open question. Several isoforms of CYP families that metabolize AA have been identified and cloned.
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Citation Information
Melissa George. "cyp450 metabolites" (2017)
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