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cyp450 metabolites
(2017)
  • Melissa George
Abstract
Arachidonic acid (AA) is a widely distributed polyunsaturated fatty acid once liberated from phospholipids by phospholipases. AA can undergo either monooxygenation or epoxidation by enzymes in the cytochrome P450 (cyp450 metabolites) family. CYP-AA metabolites include 19- and 20-hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs) and diHETEs. These metabolites have different biological functions based on sites of production- the endothelium of vessels in many organs, the lung, the tubular and corneal epithelium, the liver. The likely targets are either enzymes (Na+-K+-ATPase) or ion channels (calcium activated potassium channels). The involvement of conventional receptor physiology in the tissue responses to CYP-AA products remains an open question. Several isoforms of CYP families that metabolize AA have been identified and cloned.
Disciplines
Publication Date
2017
Citation Information
Melissa George. "cyp450 metabolites" (2017)
Available at: http://works.bepress.com/creativeproteomics/12/