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Article
Dietary fat subgroups, zinc, and vegetable components are related to urine F2a-isoprostane concentration, a measure of oxidative stress, in midlife women
Women’s Health Research Faculty Publications
  • Kristin M. Tomey, University of Michigan
  • Mary Fran R. Sowers, University of Michigan
  • Xizhao Li, University of Michigan
  • Daniel S. McConnell, University of Michigan
  • Sybil L. Crawford, University of Massachusetts Medical School
  • Ellen B. Gold, University of California at Davis
  • Bill Lasley, University of California at Davis
  • John F. Randolph, University of Michigan
UMMS Affiliation
Department of Medicine, Division of Preventive and Behavioral Medicine
Date
11-1-2007
Document Type
Article
Subjects
Adult; Biological Markers; Brassica; Dietary Fats; Female; Humans; Isoprostanes; Life Style; Longitudinal Studies; Middle Aged; *Oxidative Stress; Regression Analysis; *Vegetables; Zinc
Abstract
Smoking, diet, and physical activity may impact chronic diseases in part by promoting or attenuating oxidative stress. We evaluated associations between lifestyle factors and urine F(2a)-isoprostanes, a marker of oxidative stress in 1610 participants of the Study of Women's Health Across the Nation (SWAN). Dietary intake and physical activity were assessed at baseline and the 5th year 05 (Y05). These data were related to Y05 urinary F(2a)-isoprostane concentration with regression analyses. Median urine F(2a)-isoprostane concentration was 433 ng/L overall, 917 ng/L in smokers [inter-quartile range (IQR): 467, 1832 ng/L], and 403 ng/L in nonsmokers (IQR: 228, 709 ng/L; P < 0.0001 for difference). Higher trans fat intake was associated with higher urine F(2a)-isoprostane concentration; partial Spearman correlations (rho(x|y)) between Y05 urine F(2a)-isoprostane concentration and trans fatty acids was 0.19 (P = 0.03) in smokers and 0.13 (P < 0.0001) in nonsmokers. Increased log trans fat intake from baseline to Y05 was associated with higher concentration of log urine F(2a)-isoprostanes in nonsmokers (beta = 0.131, SE = 0.04, P = 0.0003). In nonsmokers, the partial correlation (rho(x|y)) between lutein and urine F(2a)-isoprostane concentration was -0.13 (P < 0.0001). Increased intake of log lutein from baseline to Y05 was also associated with lower log urine F(2a)-isoprostane concentration (beta = -0.096, SE = 0.03, P = 0.0005) in nonsmokers. Increased zinc intake from baseline to Y05 was associated with lower log urine F(2a)-isoprostane concentration in smokers and nonsmokers (beta = -0.346, SE = 0.14, P = 0.01), and -0.117, 0.04 (P = 0.001), respectively]. In conclusion, diet (fat subtypes, zinc, and vegetable components) and smoking were associated with urine F(2a)-isoprostanes, a marker of oxidative stress.
Rights and Permissions
Citation: J Nutr. 2007 Nov;137(11):2412-9.
Related Resources
Link to Article in PubMed
PubMed ID
17951478
Citation Information
Kristin M. Tomey, Mary Fran R. Sowers, Xizhao Li, Daniel S. McConnell, et al.. "Dietary fat subgroups, zinc, and vegetable components are related to urine F2a-isoprostane concentration, a measure of oxidative stress, in midlife women" Vol. 137 Iss. 11 (2007) ISSN: 0022-3166 (Linking)
Available at: http://works.bepress.com/crawfords/72/