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Lipid changes during the menopause transition in relation to age and weight: the Study of Women's Health Across the Nation
Women’s Health Research Faculty Publications
  • Carol A. Derby, Albert Einstein College of Medicine
  • Sybil L. Crawford, University of Massachusetts Medical School
  • Richard C. Pasternak, Merck Research Laboratories
  • Mary Fran R. Sowers, University of Michigan
  • Barbara Sternfeld, University of California at Davis
  • Karen A. Matthews, University of Pittsburgh
UMMS Affiliation
Department of Medicine, Division of Preventive and Behavioral Medicine
Publication Date
Document Type
Adult; Age Factors; *Body Weight; Estradiol; Female; Follicle Stimulating Hormone; Humans; Linear Models; Lipids; Longitudinal Studies; Menopause; Middle Aged; Prospective Studies; United States

Few studies have prospectively examined lipid changes across the menopause transition or in relation to menopausal changes in endogenous hormones. The relative independent contributions of menopause and age to lipid changes are unclear. Lipid changes were examined in relation to changes in menopausal status and in levels of estradiol and follicle-stimulating hormone in 2,659 women followed in the Study of Women's Health Across the Nation (1995-2004). Baseline age was 42-52 years, and all were initially pre- or perimenopausal. Women were followed annually for up to 7 years (average, 3.9 years). Lipid changes occurred primarily during the later phases of menopause, with menopause-related changes similar in magnitude to changes attributable to aging. Total cholesterol, low density lipoprotein cholesterol, triglycerides, and lipoprotein(a) peaked during late peri- and early postmenopause, while changes in the early stages of menopause were minimal. The relative odds of low density lipoprotein cholesterol (> or =130 mg/dL) for early postmenopausal, compared with premenopausal, women were 2.1 (95% confidence interval: 1.5, 2.9). High density lipoprotein cholesterol also peaked in late peri- and early postmenopause. Results for estradiol and follicle-stimulating hormone confirmed the results based on status defined by bleeding patterns. Increases in lipids were smallest in women who were heaviest at baseline.

DOI of Published Version
Am J Epidemiol. 2009 Jun 1;169(11):1352-61. Epub 2009 Apr 8. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
Citation Information
Carol A. Derby, Sybil L. Crawford, Richard C. Pasternak, Mary Fran R. Sowers, et al.. "Lipid changes during the menopause transition in relation to age and weight: the Study of Women's Health Across the Nation" Vol. 169 Iss. 11 (2009) ISSN: 0002-9262 (Linking)
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