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Prolonged vaginal and oral metronidazole for refractory Trichomonas vaginalis - A case report
Journal of Reproductive Medicine
  • Sara Wood
  • Colleen M. Kennedy, University of Iowa
  • Rudolph P. Galask
Document Type
Peer Reviewed
Publication Date
NLM Title Abbreviation
J Reprod Med

BACKGROUND: Resistant Trichomonas vaginalis infection is typically treated with increased doses of oral metronidazole. Because of side effects that limit compliance, such treatment may be ineffective. CASE: A young woman had an 8-year history of T vaginalis that was refractory to multiple courses of metronidazole, tinidazole and intravaginal paromomycin. After microscopic examination confirmed trichomonads, she began an extended, 14-day course of combined oral and vaginal metronidazole. Six weeks later her symptoms were unchanged, but microscopy revealed fewer trichomonads. After a 5% acetic acid vaginal wash and dilute silver nitrate bladder instillation, she was given the same treatment for 21 days. Symptoms and trichomonads resolved, and 3 years later she remained asymptomatic. CONCLUSION: Prolonged vaginal and oral metronidazole, in combination with bladder and vaginal irrigation, should be considered in women with refractory T vaginalis.

Published Article/Book Citation
Journal of Reproductive Medicine, 52:11 (2007) pp.1057-1058.
Citation Information
Sara Wood, Colleen M. Kennedy and Rudolph P. Galask. "Prolonged vaginal and oral metronidazole for refractory Trichomonas vaginalis - A case report" Journal of Reproductive Medicine Vol. 52 Iss. 11 (2007) p. 1057 - 1058 ISSN: 0024-7758
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