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Influence of hydrochlorothiazide on urinary calcium oxalate relative supersaturation in healthy young adult female domestic shorthaired cat
Veterinary Therapeutics : Research in Applied Veterinary Medicine (2007)
  • A Hezel
  • Joe W Bartges, University of Tennessee, Knoxville
  • Claudia A Kirk, University of Tennessee, Knoxville
  • Sherry Cox, University of Tennessee - Knoxville
  • N Geyer
  • T Moyers
  • J Hayes
Abstract
Hydrochlorothiazide (1 mg/kg PO q12h) or placebo was administered to healthy cats for 2 weeks in a masked, placebo-controlled, crossover-design study, and 24-hour urine samples were collected. When cats received hydrochlorothiazide, 24-hour urine volume, ammonia, chloride, creatinine, magnesium, oxalic acid, phosphate, potassium, and sodium were significantly higher than when cats received placebo. Hydrochlorothiazide was associated with significantly lower urinary saturation for calcium oxalate, but no difference was found in 24-hour urine calcium and citrate, urinary saturation for struvite, or blood ionized calcium. Hydrochlorothiazide decreased urinary saturation for calcium oxalate and could be useful in managing cats with calcium oxalate uroliths. Results of this study, however, should not be extrapolated to cats that form calcium oxalate uroliths.
Publication Date
Winter 2007
Citation Information
A Hezel, Joe W Bartges, Claudia A Kirk, Sherry Cox, et al.. "Influence of hydrochlorothiazide on urinary calcium oxalate relative supersaturation in healthy young adult female domestic shorthaired cat" Veterinary Therapeutics : Research in Applied Veterinary Medicine Vol. 8 Iss. 4 (2007)
Available at: http://works.bepress.com/claudia_kirk/48/