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Article
Analysis of Treatment Effects on the Microbial Ecology of the Human Intestine
FEMS Microbiology Ecology FEMS Microbiology Ecology
  • Anna L. Engelbrektson, California Polytechnic State University - San Luis Obispo
  • Joshua R. Korzenik, Harvard University
  • Mary Ellen Sanders, Dairy and Food Culture Technologies
  • Brian G. Clement, University of California - San Diego
  • Gregory Leyer, Danisco USA
  • Todd R. Klaenhammer, North Carolina State University at Raleigh
  • Christopher L. Kitts, California Polytechnic State University - San Luis Obispo
Publication Date
8-1-2006
Abstract
A large number of studies have investigated gastrointestinal microbiota and changes in the gastrointestinal community. However, a concern in these studies is how best to assess changes in gastrointestinal community structure. This paper presents two different human trials where the fecal terminal restriction fragment length polymorphism data sets were analyzed to search for treatment effects. Principle components analysis and cluster analysis based on grouped data are compared with analysis of data by subject using distance coefficients. Comparison with baseline within an individual before grouping by treatment provided a clearer indication of treatment effects than did an evaluation of data grouped before analysis. In addition, a large within-subject sample size and multiple baseline samples are necessary to accurately analyze treatment effects.
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Publisher statement
Author Posting. This is the author's version of the work. It is posted here by permission of Blackwell Publishing for personal use, not for redistribution.
Citation Information
Anna L. Engelbrektson, Joshua R. Korzenik, Mary Ellen Sanders, Brian G. Clement, et al.. "Analysis of Treatment Effects on the Microbial Ecology of the Human Intestine" FEMS Microbiology Ecology FEMS Microbiology Ecology Vol. 57 Iss. 2 (2006) p. 239 - 250
Available at: http://works.bepress.com/ckitts/8/