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Unpublished Paper
A CASE STUDY IN PHARMACOLOGIC IMAGING USING PRINCIPAL CURVES IN SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
Johns Hopkins University, Dept. of Biostatistics Working Papers
  • Brian S. Caffo, Department of Biostatistics, The Johns Hopkins Bloomberg School of Public Health
  • Ciprian M. Crainiceanu, Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
  • Lijuan Deng, Boston Scientific Company
  • Craig W. Hendrix, Johns Hopkins School of Medicine, Division of Clinical Pharmacology
Date of this Version
5-3-2007
Abstract
In this manuscript we are concerned with functional imaging of the colon to assess the kinetics of a microbicide lubricant. The overarching goal is to understand the distribution of the lubricant in the colon. Such information is crucial for understanding the potential impact of the microbicide on HIV viral transmission. The experiment was conducted by imaging a radiolabeled lubricant distributed in the subject’s colon. The tracer imaging was conducted via single photon emission computed tomography (SPECT), a non-invasive, in-vivo functional imaging technique. We develop a novel principal curve algorithm to construct a three dimensional curve through the colon images. The developed algorithm is tested and debugged on several difficult two dimensional images of familiar curves where the original principal curve algorithm does not apply. The final curve fit to the colon data is compared with experimental sigmoidoscope collection.
Disciplines
Citation Information
Brian S. Caffo, Ciprian M. Crainiceanu, Lijuan Deng and Craig W. Hendrix. "A CASE STUDY IN PHARMACOLOGIC IMAGING USING PRINCIPAL CURVES IN SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY" (2007)
Available at: http://works.bepress.com/ciprian_crainiceanu/29/