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Article
Obesity, weight change, and risk of adenoma recurrence: a prospective trial
Meyers Primary Care Institute Publications and Presentations
  • Adeyinka O. Laiyemo, Howard University
  • Chyke A. Doubeni, University of Massachusetts Medical School
  • Dilhana S. Badurdeen, Howard University College of Medicine
  • Gillian Murphy, Cambridge University
  • Pamela M. Marcus, National Institutes of Health
  • Robert E. Schoen, University of Pittsburgh
  • E. Lanza, National Institutes of Health
  • Duane T. Smoot, Howard University
  • A. J. Cross, National Institutes of Health
UMMS Affiliation
Department of Family Medicine and Community Health; Meyers Primary Care Institute
Publication Date
9-1-2012
Document Type
Article
Subjects
Adenoma; Colorectal Neoplasms; Body Weight Changes; Obesity
Abstract
BACKGROUND AND STUDY AIMS: Obesity is a risk factor for colorectal neoplasia. Lifestyle modifications, including weight loss, have been advocated to reduce the risk. However, no prospective study has evaluated whether weight loss actually affects adenoma recurrence. The aim of this study was to examine whether weight change (loss or gain) over 4 years is associated with adenoma recurrence. PATIENTS AND METHODS: A total of 1826 patients with colorectal adenoma in the Polyp Prevention Trial had their height and weight measured at baseline. Adenoma recurrence was determined by end of trial colonoscopy 4 years after study entry when patients' weights were re-measured. Poisson regression models were used to evaluate body mass index (BMI), weight change over 4 years, and the risk of any adenoma and advanced adenoma recurrence. RESULTS: Adenoma recurrence was observed in 723 patients (39.6%), 118 (6.5%) of whom had advanced adenoma recurrence. Among those with baseline BMI < 25 kg/m(2) (n = 466), BMI 25-29 kg/m(2) (n = 868), and BMI >/= 30 kg/m(2) (n = 492), the recurrence rate was 34.5%, 41.0%, and 41.9%, respectively. Obesity was associated with an increased risk of adenoma recurrence (RR = 1.19; 95%CI 1.01-1.39) and advanced adenoma recurrence (RR = 1.62; 95%CI 1.01-2.57). However, when compared with those with relatively stable weight (weight change < 5 lb) over the 4-year trial, weight gain or loss was not associated with adenoma recurrence. This was consistent, regardless of the baseline BMI. CONCLUSIONS: Weight loss or gain over 4 years does not affect adenoma recurrence. This study does not support weight loss alone as an effective intervention for reducing adenoma recurrence.
DOI of Published Version
10.1055/s-0032-1309837
Source

Endoscopy. 2012 Sep;44(9):813-8. doi: 10.1055/s-0032-1309837. Epub 2012 Aug 27. Link to article on publisher's site

Related Resources
Link to Article in PubMed
PubMed ID
22926666
Citation Information
Adeyinka O. Laiyemo, Chyke A. Doubeni, Dilhana S. Badurdeen, Gillian Murphy, et al.. "Obesity, weight change, and risk of adenoma recurrence: a prospective trial" Vol. 44 Iss. 9 (2012) ISSN: 0013-726X (Linking)
Available at: http://works.bepress.com/chyke_doubeni/27/