Article
Thermodynamics of Enzyme Folding and Activity: Theory and Experiment
Structure, Dynamics and Function of Biomolecules
(1987)
Abstract
The thermodynamic cycle--perturbation method is a new theoretical approach for predicting how alterations in molecular structure will change the thermodynamics of any of a large number of possible molecular processes (1–7). The structural alteration might for example be a single-site mutation in a protein or a chemical modification of a drug molecule. The process of interest might be the folding of a protein, the binding of a ligand to a receptor, the association of a repressor protein to an operator region of DNA, etc.; and the thermodynamic quantity to be predicted might be a relative free energy of folding or binding, an entropy or enthalpy of activation, or any other quantity.
Keywords
- Perturbation Method,
- Thermodynamic Cycle,
- Relative Free Energy,
- Bovine Trypsin,
- Enzyme Folding
Disciplines
Publication Date
January 1, 1987
DOI
10.1007/978-3-642-71705-5_12
Citation Information
Chung F. Wong and J. Andrew McCammon. "Thermodynamics of Enzyme Folding and Activity: Theory and Experiment" Structure, Dynamics and Function of Biomolecules (1987) p. 51 - 55 Available at: http://works.bepress.com/chung-wong/71/