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Faculty Selected Works of Chung Wong
Article
Beyond Thermodynamics: Drug Binding Kinetics Could Influence Epidermal Growth Factor Signaling
Journal of Medicinal Chemistry (2009)
  • Mayank Goyal
  • Michael Rizzo
  • Frank Schumacher
  • Chung F. Wong, University of Missouri–St. Louis
Link
Abstract
We modeled the kinetics of drug binding to protein kinases in the EGF signaling pathway relevant to non-small-cell lung cancer and found that binding kinetics could influence therapeutic potential, that fast binding kinetics was advantageous for most targets with a couple of exceptions, that targeting some protein kinases could enhance rather than attenuate the pathway, and that IC(50) could be sensitive to the kinetic parameters of drug binding.
Disciplines
Publication Date
September 24, 2009
DOI
10.1021/jm900974p
Citation Information
Mayank Goyal, Michael Rizzo, Frank Schumacher and Chung F. Wong. "Beyond Thermodynamics: Drug Binding Kinetics Could Influence Epidermal Growth Factor Signaling" Journal of Medicinal Chemistry Vol. 52 Iss. 18 (2009) p. 5582 - 5585
Available at: http://works.bepress.com/chung-wong/18/