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Article
Mechanisms for Acute Oxygen Sensing in the Carotid Body
Respiratory Physiology & Neurobiology
  • Chris Peers
  • Christopher N. Wyatt, Wright State University - Main Campus
  • A. Mark Evans
Document Type
Article
Publication Date
12-31-2010
Abstract

Hypoxic chemotransduction in the carotid body requires release of excitatory transmitters from type I cells that activate afferent sensory neurones. Transmitter release is dependent on voltage-gated Ca2+ entry which is evoked by membrane depolarization. This excitatory response to hypoxia is initiated by inhibition of specific O2 sensitive K+ channels, of which several types have been reported. Here, we discuss mechanisms which have been put forward to account for hypoxic inhibition of type I cell K+ channels. Whilst evidence indicates that one O2 sensitive K+ channel, BKCa, may be regulated by gasotransmitters (CO and H2S) in an O2-dependent manner, other studies now indicate that activation of AMP-activated protein kinase (AMPK) accounts for inhibition of both BKCa and ‘leak’ O2 sensitive K+ channels, and perhaps also other O2sensitive K+ channels reported in different species. We propose that type I cell AMPK activation occurs as a result of inhibition of mitochondrial oxidative phosphorylation, and does not require increased production of reactive oxygen species. Thus, AMPK activation provides the basis for unifying the ‘membrane’ and ‘mitochondrial’ hypotheses, previously regarded as disparate, to account for hypoxic chemotransduction.

DOI
10.1016/j.resp.2010.08.010
Citation Information
Chris Peers, Christopher N. Wyatt and A. Mark Evans. "Mechanisms for Acute Oxygen Sensing in the Carotid Body" Respiratory Physiology & Neurobiology Vol. 174 Iss. 3 (2010) p. 292 - 298 ISSN: 1569-9048
Available at: http://works.bepress.com/christopher_wyatt/36/