Article
Design and Demonstration of a Small-Animal Up-Conversion Imager
Optics Express
(2008)
Abstract
This first small-animal up-conversion imager (SAUCI) was developed and used for in-vivo imaging of up-converting nanoparticles (UCNs.) Unlike traditional fluorophores, UCNs absorb multiple lower-energy photons and emit a single higher-energy photon. This unique physical process makes it possible to image deeper into tissue with lower background signals. In vivo imaging of particle accumulation in the liver was demonstrated following intravenous injection of particles.
Keywords
- Medical and Biological imaging,
- multiphoton processes
Disciplines
Publication Date
December 16, 2008
Publisher Statement
Published in Optics Express on 16 December 2008. Published version is located at http://www.ncbi.nlm.nih.gov/pubmed/19104605
Citation Information
Christopher Salthouse, Scott Hildebrand, Ralph Weissleder and Umar Mahmood. "Design and Demonstration of a Small-Animal Up-Conversion Imager" Optics Express Vol. 16 Iss. 6 (2008) Available at: http://works.bepress.com/christopher_salthouse/1/