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Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strain.
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  • Christopher Otis, MD, Baystate Health
  • D Joseph Jerry, Baystate Health
Document Type
Article, Peer-reviewed
Publication Date
Loss of heterozygosity (LOH) occurs commonly in cancers causing disruption of tumor suppressor genes and promoting tumor progression. BALB/c-Trp53() mice are a model of Li-Fraumeni syndrome, exhibiting a high frequency of mammary tumors and other tumor ty
Publication ISSN
Citation Information
Cancer Res 2004 Aug 1;64(15):5140-7.