Skip to main content
Article
In vitro and in vivo bactericidal effect of sol-gel/antibiotic thin films on fixation devices
Key Engineering Materials
  • S. Radin
  • V. Antoci, Jr.
  • N. Hickok
  • Christopher S. Adams, Philadelphia College of Osteopathic Medicine
  • J. Parvizi
  • I. M. Shapiro
  • P. Ducheyne
Document Type
Article
Publication Date
1-1-2007
Disciplines
Abstract
Beneficial properties of room temperature processed silica sol-gels as resorbable and biocompatible materials for the controlled release of drugs and macromolecules have been described before. Recently, it was shown that a thin sol-gel film can be used for the controlled delivery of antibiotics such as vancomycin. It was also demonstrated that the release and degradation properties of the sol-gel films can be tailored via processing parameters. In this work, we evaluated the in vitro and in vivo bactericidal effects of vancomycin-containing thin sol-gel films applied on Ti-alloy intramedullary nails. Both the in vitro and the in vivo results demonstrate a pronounced bactericidal effect of the sol-gel/antibiotic films. This study suggests that thin antibiotic-containing sol-gel film holds great promise for the prevention and treatment of bone infections.
Comments

This article was published in Key Engineering Materials, Volume 330-332 II, Pages 1323-1326.

The published version is not available online.

Copyright © 2007.

Citation Information
S. Radin, V. Antoci, N. Hickok, Christopher S. Adams, et al.. "In vitro and in vivo bactericidal effect of sol-gel/antibiotic thin films on fixation devices" Key Engineering Materials Vol. 330-332 II (2007) p. 1323 - 1326
Available at: http://works.bepress.com/christopher_adams/59/