Article
Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization
Bioorganic and Medicinal Chemistry Letters
Document Type
Article
Publication Date
1-1-2007
Disciplines
Abstract
Self-protecting Ti6Al4V alloy pins were prepared by covalent bonding of bis(ethylene glycol) linkers, then vancomycin to the oxidized, aminopropylated Ti6Al4V alloy surface. Fluorescence modification-enabled estimation of yields of free amines on the metallic surface monolayer at each reaction step. The vancomycin-protected Ti6Al4V pins were not colonized by Staphylococcus aureus, even after 44 days storage in physiological buffer. These results provide a basis for testing self-protection against S. aureus colonization in animal models. © 2007 Elsevier Ltd. All rights reserved.
Citation Information
O. P. Edupuganti, V. Antoci, S. B. King, B. Jose, et al.. "Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization" Bioorganic and Medicinal Chemistry Letters Vol. 17 Iss. 10 (2007) p. 2692 - 2696 Available at: http://works.bepress.com/christopher_adams/56/
This article was published in Bioorganic and Medicinal Chemistry Letters, Volume 17, Issue 10, Pages 2692-2696.
The published version is available at http://dx.doi.org/10.1016/j.bmcl.2007.03.005.Copyright © 2007.