Skip to main content
Controlled release of vancomycin from thin sol-gel films on implant surfaces successfully controls osteomyelitis
Journal of Orthopaedic Research
  • Christopher S. Adams, Philadelphia College of Osteopathic Medicine
  • V. Antoci, Jr.
  • G. Harrison
  • P. Patal
  • T. A. Freeman
  • I. M. Shapiro
  • J. Parvizi
  • N. J. Hickok
  • S. Radin
  • P. Ducheyne
Document Type
Publication Date

Peri-prosthetic infection remains a serious complication of joint replacement surgery. Herein, we demonstrate that a vancomycin-containing sol-gelfilm on Ti alloy rods can successfully treat bacterial infections in an animal model. The vancomycin-containing sol-gel films exhibited predictable release kinetics, while significantly inhibiting S. aureus adhesion. When evaluated in a rat osteomyelitis model, microbiological analysis indicated that the vancomycin-containing sol-gel film caused a profound decrease in S. aureus number. Radiologically, while the control side showed extensive bone degradation, including abscesses and an extensive periosteal reaction, rods coated with the vancomycin-containing sol-gel film resulted in minimal signs of infection. mCT analysis confirmed the radiological results, while demonstrating that the vancomycin-containing sol-gel film significantly protected dense bone from resorption and minimized remodeling. These results clearly demonstrate that this novel thin sol-gel technology can be used for the targeted delivery of antibiotics for the treatment of periprosthetic as well as other bone infections. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.


This article was published in Journal of Orthopaedic Research, Volume 27, Issue 6, Pages 701-709.

The published version is available at

Copyright © 2009.

Citation Information
Christopher S. Adams, V. Antoci, G. Harrison, P. Patal, et al.. "Controlled release of vancomycin from thin sol-gel films on implant surfaces successfully controls osteomyelitis" Journal of Orthopaedic Research Vol. 27 Iss. 6 (2009) p. 701 - 709
Available at: