This article is designed to introduce the novice researcher to the process of journal selection, manuscript submission and manuscript review. PubMed indexing, journal readership, scope, focus, impact factor, fees and acceptable manuscript types are discussed in the first section. The remainder of this article focuses on manuscript preparation, submission and review, including formatting, pre-submission inquiry, submission portals, and the manuscript review process. Specific recommendations are provided to assist the reader in navigating these stages.